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Latest User Reviews From Our AH-Chew D Forum
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(#1)
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I just sought peer-reviewed periodicals and discovered NO EVIDENCE SUPPORTING THE EFFECTIVENESS OF PHENYLEPHRINE. "Phenylephrine, at the FDA-approved dose of 10 mg for mature persons, is improbable to supply respite of nasal congestion. It has poor oral bioavailability because of comprehensive first-pass metabolism in the gut and liver.3 Only 38% of the dose comes to the systemic circulation,3 contrasted with 90% of a pseudoephedrine dose.4 Moreover, in a randomized, twice unseeing, placebo-controlled, crossover study of 3 oral decongestants in 20 patients with chronic nasal stuffiness, phenylephrine was nothing less productive than placebo in decreasing nasal airway resistance" From the Department of Pharmacy Practice, College of Pharmacy, University of Florida, and the Drug Information Center, Shands Hospital at the University of Florida, Gainesville, Fla
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